BDBM498608 (1R,3S)-3-(3-{[(5- methoxypyridin-2- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl (1- methylcyclopropyl)carbamate::US11014911, Example 433::US11718603, Example 433

SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC2(C)CC2)nc1

InChI Key InChIKey=OXBOZUIGUJZGEF-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498608   

LigandPNGBDBM498608((1R,3S)-3-(3-{[(5- methoxypyridin-2- yl)acetyl]a...)
Affinity DataKi:  0.5nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM498608((1R,3S)-3-(3-{[(5- methoxypyridin-2- yl)acetyl]a...)
Affinity DataKi:  0.5nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498608((1R,3S)-3-(3-{[(5- methoxypyridin-2- yl)acetyl]a...)
Affinity DataKi:  17.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498608((1R,3S)-3-(3-{[(5- methoxypyridin-2- yl)acetyl]a...)
Affinity DataKi:  17.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent