BDBM498612 (1R,3S)-3-(3-{[(5- chloropyridin-2- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl (1- methylcyclopropyl)carbamate::US11014911, Example 437::US11718603, Example 437

SMILES CC1(CC1)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(Cl)cn2)n[nH]1

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498612   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498612((1R,3S)-3-(3-{[(5- chloropyridin-2- yl)acetyl]am...)
Affinity DataKi:  0.510nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498612((1R,3S)-3-(3-{[(5- chloropyridin-2- yl)acetyl]am...)
Affinity DataKi:  0.510nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498612((1R,3S)-3-(3-{[(5- chloropyridin-2- yl)acetyl]am...)
Affinity DataKi:  15.9nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498612((1R,3S)-3-(3-{[(5- chloropyridin-2- yl)acetyl]am...)
Affinity DataKi:  15.9nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent