BDBM498734 (1S,3R)-3-{3- [(phenylacetyl)amino]-1H- pyrazol-5-yl}cyclopentyl (trans- 4-hydroxy-4- methylcyclohexyl)carbamate::US11014911, Example 559::US11718603, Example 559

SMILES C[C@]1(O)CC[C@@H](CC1)NC(=O)O[C@H]1CC[C@H](C1)c1cc(NC(=O)Cc2ccccc2)n[nH]1

InChI Key InChIKey=XGSUMLPCXRCMLY-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498734   

LigandPNGBDBM498734((1S,3R)-3-{3- [(phenylacetyl)amino]-1H- pyrazol-...)
Affinity DataKi:  1.44nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

LigandPNGBDBM498734((1S,3R)-3-{3- [(phenylacetyl)amino]-1H- pyrazol-...)
Affinity DataKi:  1.44nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498734((1S,3R)-3-{3- [(phenylacetyl)amino]-1H- pyrazol-...)
Affinity DataKi:  8.58nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498734((1S,3R)-3-{3- [(phenylacetyl)amino]-1H- pyrazol-...)
Affinity DataKi:  8.58nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent