BDBM498802 (1R,3S)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl (2S,3R)-3- hydroxy-2,3-dimethylazetidine- 1-carboxylate::US11014911, Example 627::US11718603, Example 627

SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2C[C@@](C)(O)[C@@H]2C)cn1

InChI Key InChIKey=GIOBYIIPTRYRTE-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498802   

LigandPNGBDBM498802((1R,3S)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]a...)
Affinity DataKi:  0.510nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

LigandPNGBDBM498802((1R,3S)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]a...)
Affinity DataKi:  0.510nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498802((1R,3S)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]a...)
Affinity DataKi:  2.76nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498802((1R,3S)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]a...)
Affinity DataKi:  2.76nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent