BDBM50001114 8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-7,8-dihydro-3H-6,9-dioxa-3-aza-cyclopenta[a]naphthalene-2-carboxylic acid methyl ester::CHEMBL320173

SMILES COC(=O)c1cc2c3OC(CN4CCC5(CC4)N(CNC5=O)c4ccccc4)COc3ccc2[nH]1

InChI Key InChIKey=HSOIWCPMXCWYHB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50001114   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50001114(8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50001114(8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for the binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using [3H]-U-86,17...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001114(8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50001114(8-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylm...)
Affinity DataKi:  11nMAssay Description:Compound was evaluated for the binding affinity towards Alpha-1 adrenergic receptor from rat whole brain using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed