BDBM50006801 CHEMBL287012::N-Hydroxy-N-[3-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester::N-Hydroxy-N-[3-(quinolin-2-ylmethoxy)-phenyl]-succinamic acid methyl ester (Wy-45,911)

SMILES COC(=O)CCC(=O)N(O)c1cccc(OCc2ccc3ccccc3n2)c1

InChI Key InChIKey=KWMZKEYRUAAKNW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50006801   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  1.40E+3nMAssay Description:Concentration that produces 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of rat polymorphonuclear leukocyte (PMN) 5-Lipoxygenase in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  1.40E+3nMAssay Description:Ability to inhibit Lipoxygenase in vitro was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  4.00E+4nMAssay Description:In vitro inhibition of rat polymorphonuclear leukocyte (PMN) Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  4.00E+4nMAssay Description:Ability to inhibit the rat PMN (polymorphonuclear leukocyte) CO (cyclo-oxygenase) in vitro was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  4.04E+4nMAssay Description:Concentration that produces 50% inhibition of A-23187-stimulated radiolabeled 5-HETE and TXB2 synthesis by PMN (Prostaglandin G/H synthase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006801(CHEMBL287012 | N-Hydroxy-N-[3-(quinolin-2-ylmethox...)
Affinity DataIC50:  1.40E+3nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase receptor in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed