BDBM50009859 (+-)-2-(p-isobutylphenyl)propionic acid::(+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid::(+-)-ibuprofen::(+-)-p-isobutylhydratropic acid::(4-isobutylphenyl)-alpha-methylacetic acid::(RS)-ibuprofen::2-(4-isobutylphenyl)propanoic acid::2-[4-(2-methylpropyl)phenyl]propanoic acid::4-isobutylhydratropic acid::Advil::Brufen::CHEMBL521::IBUPROFEN LYSINE::Ibuprofen::Ibuprofen (1)::Motrin::alpha-(4-isobutylphenyl)propionic acid::alpha-(p-isobutylphenyl)propionic acid
SMILES CC(C)Cc1ccc(cc1)[C@H](C)C(=O)O
InChI Key InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 165 hits for monomerid = 50009859
Affinity DataIC50: 100nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of COX-1 in human washed platelet assessed as inhibition of 0.5 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to ...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Reversible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin produc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX-2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro inhibitory concentration against COX-2 enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of bovine COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human COX2 expressed in baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant COX-2More data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataKd: 1.47E+3nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of COX2 (unknown origin) assessed as reduction in PGF2alpha content using arachidonic acid as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of COX-1 in human washed platelet assessed as inhibition of 10 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of ovine COX-1 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for 5 mins foll...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate readerMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:In vitro inhibitory concentration against COX-1 enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of sheep COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of bovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair

3D Structure (crystal)