BDBM50017811 CHEMBL467::HU::US10155732, Compound HU::hydroxyurea

SMILES NC(=O)NO

InChI Key InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N

Data  4 KI  6 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50017811   

TargetCarbonic anhydrase 9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of human CA9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of human CA5aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataKi:  1.13E+5nMAssay Description:Inhibition of human CA4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit(Homo sapiens (Human))
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataIC50:  9.97E+5nMAssay Description:Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetStromelysin-1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM50017811(CHEMBL467 | HU | US10155732, Compound HU | hydroxy...)
Affinity DataIC50:  1.48E+5nMAssay Description:A diverse compound library from NCI Developmental Therapeutics Program (DTP) was subjected to a virtual screening process to identify potential RR in...More data for this Ligand-Target Pair
In DepthDetails US Patent