BDBM50021656 BARICITINIB::INCB-028050::LY-3009104::US10112907, Example 00034::US10766894, Compound TABLE 1.19::US10875847, Compound Baricitinib::US11203595, TABLE 1.19::US11414413, Example Baricitinib::US20230416237, Example baricitinib::US20240140952, Compound Baricitinib
SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
InChI Key InChIKey=XUZMWHLSFXCVMG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 118 hits for monomerid = 50021656
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human JAK2 by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of JAK2 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:Inhibition of JAK1 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) using FITC-Ahx-KKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in the presence of ATP by ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 (850 to 1154 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant JAK2 (828 to 1132 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Reversible inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant epitope tagged JAK2 (unknown origin) (828 to 1132 residues) using peptide as substrate in presence of ATP by homogeneous ti...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of JAK2 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant epitope tagged JAK2 kinase domain (828 to 1132 residues) (unknown origin) using peptide substrate by fluorescence based ass...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant epitope tagged JAK2 (unknown origin) (828 to 1132 residues) using peptide substrate in presence of ATP by time-resolved flu...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant epitope tagged JAK1 (unknown origin) (837 to 1142 residues) using peptide substrate in presence of ATP by time-resolved flu...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant JAK1 (837 to 1142 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Reversible inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant epitope tagged JAK1 (unknown origin) (837 to 1142 residues) using peptide as substrate in presence of ATP by homogeneous ti...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of JAK 1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant epitope tagged JAK1 kinase domain (837 to 1142 residues) (unknown origin) using peptide substrate by fluorescence based ass...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of JAK1 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair