BDBM50022721 (R)-amphetamine::AMPHETAMINE::CHEMBL19393

SMILES C[C@@H](N)Cc1ccccc1

InChI Key InChIKey=KWTSXDURSIMDCE-UHFFFAOYSA-N

Data  6 KI  16 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50022721   

TargetTrace amine-associated receptor 1(Rhesus macaque)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  1.86E+3nMAssay Description:Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  786nMAssay Description:Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  105nMAssay Description:Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  34nMAssay Description:Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  121nMAssay Description:Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  214nMAssay Description:Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  170nMAssay Description:Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  250nMAssay Description:Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  1.70E+3nMAssay Description:Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  65nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  4.96E+3nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  1.40E+3nMAssay Description:Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  210nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  280nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataEC50:  920nMAssay Description:Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataKi:  4.64E+4nMAssay Description:Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataKi:  1.38E+6nMAssay Description:Inhibitory activity against bovine adrenal norepinephrine N-methyl-transferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataKi:  1.80E+5nMAssay Description:Competitive inhibition of Bovine liver Monoamine Oxidase B at 30 degree C (pH= 9.0)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Bovine)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataKi:  3.80E+5nMAssay Description:In vitro inhibition of bovine monoamine oxidase B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataKi:  7.60E+5nMAssay Description:Competitive inhibition of Rat liver Monoamine Oxidase B at 30 degree C (pH= 7.2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50022721((R)-amphetamine | CHEMBL19393 | AMPHETAMINE)
Affinity DataKi:  1.38E+6nMAssay Description:In vitro binding affinity of compound towards bovine adrenal phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed