BDBM500350 4-(7-methoxy- 1H-indol-3- yl-)-7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]-2,3- dihydropyrrolo [3,4-c]pyridin-1-one::US11021481, Compound I-7::US11078201, Compound I-7::US11548890, Compound I-7

SMILES COc1cccc2c(c[nH]c12)-c1ncc(Nc2ccc(cn2)N2CCN(C)CC2)c2C(=O)NCc12

InChI Key InChIKey=CBRKPHRURYWWAO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500350   

LigandPNGBDBM500350(US11021481, Compound I-7 | 4-(7-methoxy- 1H-indol-...)
Affinity DataIC50: 300nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500350(US11021481, Compound I-7 | 4-(7-methoxy- 1H-indol-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500350(US11021481, Compound I-7 | 4-(7-methoxy- 1H-indol-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500350(US11021481, Compound I-7 | 4-(7-methoxy- 1H-indol-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500350(US11021481, Compound I-7 | 4-(7-methoxy- 1H-indol-...)
Affinity DataIC50: 550nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent