BDBM500388 4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl)-2-pyridyl]amino] isoindolin-1-one::US11021481, Compound I-46::US11078201, Compound I-46::US11548890, Compound I-46

SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2c[nH]c3ccccc23)nc1

InChI Key InChIKey=ZNWUGMWXLLYSCQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500388   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500388(4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500388(4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500388(4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500388(4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500388(4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent