BDBM50040065 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one::CARTEOLOL::CHEMBL839

SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12

InChI Key InChIKey=LWAFSWPYPHEXKX-UHFFFAOYSA-N

Data  1 KI  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50040065   

TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Università di Perugia

Curated by ChEMBL
LigandPNGBDBM50040065(5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihyd...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12
Show InChI InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50040065(5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihyd...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12
Show InChI InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20)
Affinity DataIC50: 1.00E+6nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair