BDBM50048908 CHEMBL415788
SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O
InChI Key InChIKey=DQDBCHHEIKQPJD-ODKJCKIQSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50048908
Affinity DataKi: 0.129nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Binding affinity to human NTS1RMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 0.550nMAssay Description:Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter...More data for this Ligand-Target Pair
Affinity DataKi: 0.741nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [125I]-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter metho...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.60nMAssay Description:Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonist activity at human NTS1 expressed in HEK293 cells co-expressing Galphaq/RlucII/GFP10-Ggamma1/Gbeta1 assessed as increase in Galphaq activation...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0692nMAssay Description:Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescenc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mi...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mi...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 m...More data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 min...More data for this Ligand-Target Pair
Affinity DataIC50: 0.407nMAssay Description:Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analy...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analy...More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive r...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contractionMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitm...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0420nMAssay Description:Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ l...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulat...More data for this Ligand-Target Pair