BDBM50051169 CHEMBL409974::Cyclic Lactam Peptide Analogues of Dynorphin A(1-11)-NH2

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCCN)C(N)=O

InChI Key InChIKey=OKJAOUBQLSWUNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50051169   

TargetKappa-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50051169(Cyclic Lactam Peptide Analogues of Dynorphin A(1-1...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of plasma membrane homogenates of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50051169(Cyclic Lactam Peptide Analogues of Dynorphin A(1-1...)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50051169(Cyclic Lactam Peptide Analogues of Dynorphin A(1-1...)
Affinity DataIC50: 26nMAssay Description:Compound was tested for the inhibition of binding of [3H]c[D-Pen2,p-Cl-Phe4,D-Pen5]enkephalin to Opioid receptor delta 1 in plasma membrane homogenat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed