BDBM500537 4-[7-(hydroxymeth- yl)imidazo[1,2- a]pyridin-3- yl]-7-[(5- morpholino-2- pyridyl)amino] isoindolin-1-one::US11021481, Compound I-196::US11548890, Compound I-196

SMILES OCc1ccn2c(cnc2c1)-c1ccc(Nc2ccc(cn2)N2CCOCC2)c2C(=O)NCc12

InChI Key InChIKey=NYMSFEGUQIJSPB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 500537   

LigandPNGBDBM500537(US11021481, Compound I-196 | 4-[7-(hydroxymeth- yl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500537(US11021481, Compound I-196 | 4-[7-(hydroxymeth- yl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500537(US11021481, Compound I-196 | 4-[7-(hydroxymeth- yl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM500537(US11021481, Compound I-196 | 4-[7-(hydroxymeth- yl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent