BDBM50055218 1-(2-naphthlmethyl) isatin-5-carboxamide::1-Naphthalen-2-ylmethyl-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxylic acid amide::CHEMBL358279::acs.jmedchem.1c00409_ST.74::med.21724, Compound 108

SMILES NC(=O)c1ccc2N(Cc3ccc4ccccc4c3)C(=O)C(=O)c2c1

InChI Key InChIKey=NTNYHMJYSGPGCQ-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50055218   

TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataKi:  4nMAssay Description:Inhibition of human rhinovirus 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(SARS-CoV)
Michigan State University

LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataKi:  120nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetChymotrypsinogen B(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human rhinovirus 14 3C proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  300nMAssay Description:Inhibition of SARS-CoV-2 MPro using MCAAVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubated for 10 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(SARS-CoV)
Michigan State University

LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  370nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  45nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(SARS-CoV)
Michigan State University

LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  370nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  45nMAssay Description:Inhibition of N-terminal full length SARS-CoV-2 Main protease using Thr-Ser-Ala-Val-Leu-Gln-pNA as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTrypsin(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  3.52E+5nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  370nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPapain(Papaya)
Peking University

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of papainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed