BDBM50056570 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(2-naphthalen-1-yl-ethyl)-piperazine::CHEMBL162828

SMILES Fc1ccc(cc1)C(OCCN1CCN(CCc2cccc3ccccc23)CC1)c1ccc(F)cc1

InChI Key InChIKey=PDIYHRCAHJQIGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50056570   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056570(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(2-n...)
Affinity DataIC50: 7.80nMAssay Description:Binding affinity at the dopamine transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056570(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(2-n...)
Affinity DataIC50: 25nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056570(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(2-n...)
Affinity DataIC50: 46nMAssay Description:Binding affinity at the serotonin transporter using [125I]RTI-55 in rat caudate membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50056570(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(2-n...)
Affinity DataIC50: 119nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed