BDBM50058349 CHEMBL3331254::US9604926, Compound SN-251::US9724435, Compound SN-251

SMILES O=c1oc2ccccc2n1CCCCN1CCN(CC1)c1ccccc1

InChI Key InChIKey=CRQMQCDWCBHDSI-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50058349   

TargetSigma intracellular receptor 2(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50058349(CHEMBL3331254 | US9604926, Compound SN-251 | US972...)
Affinity DataKi:  11.4nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Rat)
The University of Mississippi

US Patent
LigandPNGBDBM50058349(CHEMBL3331254 | US9604926, Compound SN-251 | US972...)
Affinity DataKi:  11.4nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50058349(CHEMBL3331254 | US9604926, Compound SN-251 | US972...)
Affinity DataKi:  18.4nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

US Patent
LigandPNGBDBM50058349(CHEMBL3331254 | US9604926, Compound SN-251 | US972...)
Affinity DataKi:  18.4nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 7(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50058349(CHEMBL3331254 | US9604926, Compound SN-251 | US972...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50058349(CHEMBL3331254 | US9604926, Compound SN-251 | US972...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed