BDBM50059863 (Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid::CHEMBL103955::chaetomellic acid A

SMILES CCCCCCCCCCCCCC\C(C(O)=O)=C(/C)C(O)=O

InChI Key InChIKey=ULSDRNDLXFVDED-MSUUIHNZSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059863   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Alexandru Ioan Cuza University

Curated by ChEMBL
LigandPNGBDBM50059863((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Alexandru Ioan Cuza University

Curated by ChEMBL
LigandPNGBDBM50059863((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Alexandru Ioan Cuza University

Curated by ChEMBL
LigandPNGBDBM50059863((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Affinity DataIC50:  175nMAssay Description:Inhibition of human recombinant FTase by fluorescent-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059863((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Affinity DataIC50:  9.20E+4nMAssay Description:In vitro inhibition of geranylgeranyl-protein transferase type-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Alexandru Ioan Cuza University

Curated by ChEMBL
LigandPNGBDBM50059863((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Affinity DataIC50:  60nMAssay Description:Activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed