BDBM50061891 9-{3-[4-(6-Isothiocyanato-hexyl)-3,5-dimethyl-piperazin-1-yl]-propyl}-9H-carbazole::CHEMBL138438

SMILES CC1CN(CCCn2c3ccccc3c3ccccc23)CC(C)N1CCCCCCN=C=S

InChI Key InChIKey=MUVARIKITYVRFW-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50061891   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061891(9-{3-[4-(6-Isothiocyanato-hexyl)-3,5-dimethyl-pipe...)
Affinity DataKd:  7.60nMAssay Description:Dissociation constant(KD) of [3H]WIN-35428 at saturation in rat caudate-putamen tissue pre-incubated in buffer at 100 nM (Dopamine transporter)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061891(9-{3-[4-(6-Isothiocyanato-hexyl)-3,5-dimethyl-pipe...)
Affinity DataIC50:  87nMAssay Description:Binding affinity was evaluated using [3H]WIN-35428 binding to dopamine transporter (DAT) in rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061891(9-{3-[4-(6-Isothiocyanato-hexyl)-3,5-dimethyl-pipe...)
Affinity DataKd:  7.60nMAssay Description:Dissociation constant(KD) of [3H]WIN-35428 at saturation in rat caudate-putamen tissue pre-incubated in buffer at 100 nM (Dopamine transporter)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061891(9-{3-[4-(6-Isothiocyanato-hexyl)-3,5-dimethyl-pipe...)
Affinity DataIC50:  707nMAssay Description:Binding affinity was evaluated using [3H]pentazocine binding to sigma-1 receptor from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061891(9-{3-[4-(6-Isothiocyanato-hexyl)-3,5-dimethyl-pipe...)
Affinity DataKd:  17nMAssay Description:Dissociation constant(KD) of [3H]WIN-35428 at saturation in rat caudate-putamen tissue pre-incubated in buffer (Dopamine transporter)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed