BDBM67544 N,N-dimethyl-3-[2-(trifluoromethyl)-10-phenothiazinyl]-1-propanamine;hydrochloride::N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride::SR-01000000224-4::TRIFLUPROMAZINE::cid_66069::dimethyl-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]amine;hydrochloride::med.21724, Compound Triflupromazine

SMILES CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F

InChI Key InChIKey=XSCGXQMFQXDFCW-UHFFFAOYSA-N

Data  9 KI  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 67544   

TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  52nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  530nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  530nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  605nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetPleiotropic ABC efflux transporter of multiple drugs(Baker's yeast)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataEC50:  5.75E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataEC50:  6.39E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataEC50:  7.80E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  1.57E+4nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNADPH oxidase 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataIC50: 1.70E+4nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  3.02E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed