BDBM50067028 (1E,4E)-1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one::(1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one::1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one::1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one::1,5-bis-(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one::CHEMBL128729::Go-Y022
SMILES COc1cc(\C=C\C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
InChI Key InChIKey=ISIMGBQRFXXNON-FCXRPNKRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50067028
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 7.09E+4nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom...More data for this Ligand-Target Pair
Affinity DataIC50: >200nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 292nMAssay Description:Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uMMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 257nMAssay Description:Inhibition of human 11beta-HSD1 transfected in CHOP cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 4.15E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataEC50: 900nMAssay Description:Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinoneMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 4.15E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibitory activity against HIV-1 Integrase (HIV-1-IN)More data for this Ligand-Target Pair
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataEC50: 9.90E+3nMAssay Description:Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Wenzhou Medical College
Curated by ChEMBL
Wenzhou Medical College
Curated by ChEMBL
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT after 60 to 90 mins by radiometric an...More data for this Ligand-Target Pair