BDBM50067319 4-{(E)-2-[({[2,4-Dimethyl-3-(1-methyl-2-methylamino-1H-benzoimidazol-4-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-vinyl}-N-methyl-benzamide::CHEMBL288079

SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4n(C)c(NC)nc34)c2C)cc1

InChI Key InChIKey=LJIWXRWHECFROH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50067319   

TargetB2 bradykinin receptor(Guinea pig)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067319(4-{(E)-2-[({[2,4-Dimethyl-3-(1-methyl-2-methylamin...)
Affinity DataIC50: 94nMAssay Description:Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067319(4-{(E)-2-[({[2,4-Dimethyl-3-(1-methyl-2-methylamin...)
Affinity DataIC50: 94nMAssay Description:In vitro inhibitory activity towards bradykinin receptor B2 using [3H]BK (0.06 nM) as a radioligand in guinea pig ileum membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067319(4-{(E)-2-[({[2,4-Dimethyl-3-(1-methyl-2-methylamin...)
Affinity DataIC50: 94nMAssay Description:Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067319(4-{(E)-2-[({[2,4-Dimethyl-3-(1-methyl-2-methylamin...)
Affinity DataIC50: 670nMAssay Description:In vitro inhibitory activity towards human bradykinin receptor B2 expressed in CHO cells using [3H]BK (1.0 nM) as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed