BDBM50072452 3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10a-hexahydro-2H-benzo[g]isoquinolin-4a-yl)-phenol::CHEMBL107398

SMILES C[C@@]12CN(CCc3ccccc3)CC[C@@]1(Cc1ccccc1C2)c1cccc(O)c1

InChI Key InChIKey=ITGNKLZJCRMFGA-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50072452   

TargetKappa-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50072452(3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10...)
Affinity DataKi:  6.60nMAssay Description:Compound was tested for the inhibition of [35S]GTP-gamma-S, binding Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50072452(3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity was determined as ability to displace [3H]-U-69, radioligand from Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50072452(3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10...)
Affinity DataKi:  10nMAssay Description:Binding affinity was determined against Mu opioid receptor using [3H]naltrexone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50072452(3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10...)
Affinity DataKi:  11nMAssay Description:Binding affinity was determined as ability to displace [3H]DAMGO radioligand from Mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50072452(3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10...)
Affinity DataKi:  184nMAssay Description:Compound was tested for the inhibition of [35S]GTP-gamma-S, binding in Guinea pig Caudate stimulated by the Opioid receptor delta 1 agonist Delta-SNC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50072452(3-((4aS,10aS)-10a-Methyl-2-phenethyl-1,3,4,5,10,10...)
Affinity DataKi:  1.27E+3nMAssay Description:Binding affinity was determined as ability to displace [3H]DADLE radioligand from Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed