BDBM50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE

SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1

InChI Key InChIKey=PHLBKPHSAVXXEF-UHFFFAOYSA-N

Data  44 KI  12 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 59 hits for monomerid = 50073444   

Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  1.94nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataIC50: 17nMAssay Description:Compound was tested for the inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  19.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  29nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  44.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  73.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]-5HT from human 5-HT2B receptor expressed in african green monkey COS7 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  83.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  84nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  96nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  106nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  112nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  118nMAssay Description:Displacement of 8-OH-DPAT from human 5-HT1AR in human brain frontal cortex incubated for 30 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  193nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  224nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  224nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  237nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataIC50: 243nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin) by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  243nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  252nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataIC50: 281nMAssay Description:Binding affinity by its ability to displace [3H]prazosin radioligand from Alpha-1 adrenergic receptor on rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2018
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  402nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  690nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataEC50:  785nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  1.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetHLA class I histocompatibility antigen, A alpha chain(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to human biotinylated HLA-A2 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  3.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  3.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataIC50: 4.49E+3nMAssay Description:Antagonist activity at D2 receptor (unknown origin) by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  7.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetAlbumin(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKd:  7.95E+3nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2016
Entry Details Article
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi:  8.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50073444(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 59 total ) | Next | Last >>