BDBM50091818 CHEMBL61743::Isoquinolin-3-ylamine::uPa_46

SMILES Nc1cc2ccccc2cn1

InChI Key InChIKey=VYCKDIRCVDCQAE-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50091818   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Csar

LigandPNGBDBM50091818(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Affinity DataKi: >3.00E+4nM ΔG°: >-6.17kcal/molepH: 7.4 T: 2°CAssay Description:Abbott uPA__Urokinase Human - Ki(uM)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50091818(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Affinity DataKi: >3.00E+4nMAssay Description:Photometric_Method1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091818(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50091818(CHEMBL61743 | Isoquinolin-3-ylamine | uPa_46)
Affinity DataIC50:  3.76E+5nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed