BDBM50096348 2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid::Bardoxolone::CDDO::CDDO, 5::RTA-401

SMILES [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(O)=O

InChI Key InChIKey=TXGZJQLMVSIZEI-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50096348   

TargetGhrelin O-acyltransferase(Human)
Syracuse University

LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataIC50: 1.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataIC50: 23nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataKd:  4.87E+4nMAssay Description:Binding affinity to Keap1 (unknown origin) assessed as dissociation constant incubated for 200 sec by sensor chip immobilization based surface plasmo...More data for this Ligand-Target Pair
In DepthDetails
PubMed