BDBM50113281 AT-7519::US20240293557, Compound AMC-3-098

SMILES c1cc(c(c(c1)Cl)C(=O)Nc2c[nH]nc2C(=O)NC3CCNCC3)Cl

InChI Key InChIKey=OVPNQJVDAFNBDN-UHFFFAOYSA-N

Data  9 KI  53 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 72 hits for monomerid = 50113281   

TargetCyclin-dependent kinase 9(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 2.06nMAssay Description:CDK9 activity assays were performed by Nanosyn using a microfluidics mobility shift platform. In this assay, a fluorescently labeled substrate is inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 14(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 2.20nMAssay Description:Lanthascreen Eu kinase binding assays were conducted for Cdk14/CycY largely as performed in the commercial assay service by Life Technologies, but in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 16(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 3.90nMAssay Description:Lanthascreen Eu kinase binding assays were conducted for Cdk14/CycY largely as performed in the commercial assay service by Life Technologies, but in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full-length C-terminal His6-tagged CDK9/human full-length untagged cyclin T1 expressed in baculovirus infected Sf21 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CDK5/N-terminal GST-tagged p25 expressed in baculovirus infected Sf21 insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-Y(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant GST-tagged human full length CDK14/cyclin Y (2 to end residues) preincubated for 30 mins by Lantha screen eu binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 27.4nMAssay Description:Lanthascreen Eu kinase binding assays were conducted for Cdk14/CycY largely as performed in the commercial assay service by Life Technologies, but in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 32nMAssay Description:Inhibition of CDK2/cyclin A2 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataKi:  44nMAssay Description:Inhibition of human full length C-terminal His6-tagged CDK2/N-terminal GST-tagged cyclin A expressed in baculovirus infected Sf21 insect cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate measured after 4 hrs in presence of ATP by radiometric filter-binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataKi:  47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataKi:  67nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4/cyclin D1 expressed in baculovirus infected sf cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 72nMAssay Description:Inhibition of CDK4/cyclin D3 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 89nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 89nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 98nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) using GST-tagged pRb (769 to 921 residues) as substrate measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK9 (unknown origin) preincubated for 20 mins followed by [gamma-33P]ATP addition measured after 120 mins in presence of ATP by Hot-Sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataKi: <100nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK9/cyclin T1 expressed in baculovirus infected Sf21 insect cells using PDKtide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclin-dependent kinase 14(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 110nMAssay Description:Lanthascreen Eu kinase binding assays were conducted for Cdk14/CycY largely as performed in the commercial assay service by Life Technologies, but in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) incubated for 30 mins in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
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