BDBM50114423 MYRTUCOMMULONE A

SMILES CC(C)[C@@H](C1=C(O)C(C)(C)C(=O)C(C)(C)C1=O)c1c(O)c([C@@H](C(C)C)C2=C(O)C(C)(C)C(=O)C(C)(C)C2=O)c(O)c(C(=O)C(C)C)c1O

InChI Key InChIKey=BIHONVMOJSPPFL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50114423   

TargetProstaglandin E synthase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of 5-LO in ionomycin-stimulated human PMNL using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli JM109 using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
University of Jena

Curated by ChEMBL
LigandPNGBDBM50114423(MYRTUCOMMULONE A)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of COX-1 in human platelet using arachidonic acid as substrate assessed as formation of 12-HHT preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed