BDBM50114789 CHEMBL3609747

SMILES OC(=O)[C@H](CC1CCC1)c1cc(Cl)c(OCC(F)(F)F)c(c1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=ZSERTYLZGRJLOO-QGZVFWFLSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50114789   

LigandPNGBDBM50114789(CHEMBL3609747)
Affinity DataIC50:  67nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing wild type APP751 assessed as inhibition of intracellular amyloid beta 42 production after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50114789(CHEMBL3609747)
Affinity DataEC50:  70nMAssay Description:Inhibition of amyloid beta 42 in human H4 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPresenilin-1(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50114789(CHEMBL3609747)
Affinity DataIC50:  67nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated for 16 to 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50114789(CHEMBL3609747)
Affinity DataEC50:  67nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as inhibition of amyloid beta 42 production after 16 to 18 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed