BDBM50114789 CHEMBL3609747
SMILES OC(=O)[C@H](CC1CCC1)c1cc(Cl)c(OCC(F)(F)F)c(c1)-c1ccc(cc1)C(F)(F)F
InChI Key InChIKey=ZSERTYLZGRJLOO-QGZVFWFLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50114789
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing wild type APP751 assessed as inhibition of intracellular amyloid beta 42 production after ...More data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Inhibition of amyloid beta 42 in human H4 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated for 16 to 1...More data for this Ligand-Target Pair
Affinity DataEC50: 67nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as inhibition of amyloid beta 42 production after 16 to 18 hrs by EL...More data for this Ligand-Target Pair