BDBM50118223 AR-C67085::Adenosine triphosphate derivative::CHEMBL336292::CHEMBL369928

SMILES CCCSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)c2n1

InChI Key InChIKey=ZLIAJZQKKBOFJR-WOUKDFQISA-N

Data  2 IC50  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50118223   

TargetP2Y purinoceptor 12(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50118223(AR-C67085 | Adenosine triphosphate derivative | CH...)
Affinity DataKd:  4.57nMAssay Description:Binding affinity to P2Y12 receptor expressed in human platelets from 0.047 to 50 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50118223(AR-C67085 | Adenosine triphosphate derivative | CH...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50118223(AR-C67085 | Adenosine triphosphate derivative | CH...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50118223(AR-C67085 | Adenosine triphosphate derivative | CH...)
Affinity DataEC50:  1.30nMAssay Description:The compound was evaluated for antagonist activity against platelet P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 11(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118223(AR-C67085 | Adenosine triphosphate derivative | CH...)
Affinity DataEC50:  1.50E+3nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed