BDBM50120469 2-[1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)]-3-yl]-1-ethanol::CHEMBL144662

SMILES OCCC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1

InChI Key InChIKey=GUMKVHJWYPTYLU-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50120469   

TargetSigma non-opioid intracellular receptor 1(Human)
Pharmazeutisches Institut Der Universit£T Freiburg

Curated by ChEMBL
LigandPNGBDBM50120469(2-[1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Affinity DataKi:  12.7nMAssay Description:Ability to displace [3H](+)-pentazocine from Sigma opioid receptor type 1 of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50120469(2-[1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2017
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Pharmazeutisches Institut Der Universit£T Freiburg

Curated by ChEMBL
LigandPNGBDBM50120469(2-[1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Affinity DataKi:  8.46E+3nMAssay Description:Ability to displace [3H]ditolylguanidine in the presence of 100 nM (+)-pentazocine from Sigma opioid receptor type 2 of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed