BDBM50124602 (5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-yloxy)-acetonitrile::CHEMBL8055

SMILES COc1c(OCC#N)ccc2OC(CC=C)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=BXRWJRAKHHVCNU-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50124602   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124602((5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H...)
Affinity DataKi:  51nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124602((5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H...)
Affinity DataEC50:  130nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124602((5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H...)
Affinity DataKi:  3.08E+3nMAssay Description:Displacement of [3H]progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed