BDBM50129167 2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene::CHEMBL293409

SMILES CC1CC(C)(C)Nc2ccc-3c(COc4ccc(cc-34)[N+]([O-])=O)c12

InChI Key InChIKey=JXCHEAFROKFUTG-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50129167   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129167(2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-ox...)
Affinity DataEC50:  52nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129167(2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-ox...)
Affinity DataIC50: 63nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129167(2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-ox...)
Affinity DataIC50: 104nMAssay Description:Inhibition of human progesterone receptor activation in T47D human breast cancer cell.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129167(2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-ox...)
Affinity DataKi:  144nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129167(2,2,4-Trimethyl-9-nitro-2,3,4,5-tetrahydro-1H-6-ox...)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of antagonist activity towards glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed