BDBM50130880 CHEMBL407196::NT(1-13)::neurotensin::pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu::pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#8])=O
InChI Key InChIKey=PCJGZPGTCUMMOT-ISULXFBGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 50130880
Affinity DataKi: 0.170nMAssay Description:Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cereb...More data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Binding affinity to human NTS1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
Affinity DataKi: 1.64nMAssay Description:Displacement of [125I]I-Tyr(3)NT from human NTR1More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter a...More data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma cou...More data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Displacement of [3H]NT from human NTS2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.590nMAssay Description:Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideMore data for this Ligand-Target Pair
Affinity DataIC50: 0.620nMAssay Description:Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsMore data for this Ligand-Target Pair
Affinity DataKd: 0.510nMAssay Description:Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Displacement of [3H]-neurotensin from human sortilin incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintillation proxi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Binding affinity to human NTS1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting m...More data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human NTR1More data for this Ligand-Target Pair
Affinity DataIC50: 6.03nMAssay Description:Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins befo...More data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human NTR2More data for this Ligand-Target Pair
Affinity DataEC50: 0.230nMAssay Description:Agonist activity at NTR1 (unknown origin) expressed in CHOK1 cells by calcium mobilization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human NTR1 assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.98nMAssay Description:Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.19nMAssay Description:Displacement of [125I]I-Tyr(3)NT from human NTR1More data for this Ligand-Target Pair
Affinity DataEC50: >100nMAssay Description:Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Antagonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR ...More data for this Ligand-Target Pair
Affinity DataIC50: 114nMAssay Description:Antagonist activity at rat NTS2 receptor expressed in CHO-K1 cells assessed as inhibition of SR142948a-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activit...More data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activit...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair