BDBM50132411 5-(3-tert-Butyl-5-{3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureido}-pyrazol-1-yl)-2-methyl-benzoic acid::CHEMBL420474

SMILES Cc1ccc(cc1C(O)=O)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C

InChI Key InChIKey=ZSGYFOODLVWHNS-UHFFFAOYSA-N

Data  1 Kd  2 Koff  1 Kon

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132411   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50132411(5-(3-tert-Butyl-5-{3-[4-(2-morpholin-4-yl-ethoxy)-...)
Show SMILES Cc1ccc(cc1C(O)=O)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H37N5O5/c1-21-9-10-22(19-25(21)30(38)39)37-29(20-28(35-37)32(2,3)4)34-31(40)33-26-11-12-27(24-8-6-5-7-23(24)26)42-18-15-36-13-16-41-17-14-36/h5-12,19-20H,13-18H2,1-4H3,(H,38,39)(H2,33,34,40)
Affinity DataKd:  2.5nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50132411(5-(3-tert-Butyl-5-{3-[4-(2-morpholin-4-yl-ethoxy)-...)
Show SMILES Cc1ccc(cc1C(O)=O)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H37N5O5/c1-21-9-10-22(19-25(21)30(38)39)37-29(20-28(35-37)32(2,3)4)34-31(40)33-26-11-12-27(24-8-6-5-7-23(24)26)42-18-15-36-13-16-41-17-14-36/h5-12,19-20H,13-18H2,1-4H3,(H,38,39)(H2,33,34,40)
Affinity DataKon:  0.0000620M-1s-1 Koff:  2.52E+4s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50132411(5-(3-tert-Butyl-5-{3-[4-(2-morpholin-4-yl-ethoxy)-...)
Show SMILES Cc1ccc(cc1C(O)=O)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H37N5O5/c1-21-9-10-22(19-25(21)30(38)39)37-29(20-28(35-37)32(2,3)4)34-31(40)33-26-11-12-27(24-8-6-5-7-23(24)26)42-18-15-36-13-16-41-17-14-36/h5-12,19-20H,13-18H2,1-4H3,(H,38,39)(H2,33,34,40)
Affinity DataKon:  0.0000620M-1s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair