BDBM50136197 1-[1-(4-Fluoro-phenyl)-piperidin-4-yl]-4-(4-nitro-phenoxy)-4-phenyl-butan-1-one::CHEMBL153391

SMILES [O-][N+](=O)c1ccc(OC(CCC(=O)C2CCN(CC2)c2ccc(F)cc2)c2ccccc2)cc1

InChI Key InChIKey=GRNIONRZPGYZTD-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50136197   

Target5-hydroxytryptamine receptor 2A(Rat)
Faes Farma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136197BDBM50136197(1-[1-(4-Fluoro-phenyl)-piperidin-4-yl]-4-(4-nitro-...)
Affinity DataKi:  23nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]ketanserin from rat prefrontal cerebral cortex mambranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Faes Farma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136197BDBM50136197(1-[1-(4-Fluoro-phenyl)-piperidin-4-yl]-4-(4-nitro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Faes Farma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136197BDBM50136197(1-[1-(4-Fluoro-phenyl)-piperidin-4-yl]-4-(4-nitro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against serotonin transporter (SERT) by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed