BDBM50140548 3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-5-fluoro-4-oxo-pentanoic acid methyl ester::CHEMBL23453::acs.jmedchem.1c00409_ST.196

SMILES COC(=O)CC(NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)CF

InChI Key InChIKey=DPHACENAZHGWHS-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50140548   

TargetCalpain-1 catalytic subunit(Human)
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 120nMAssay Description:Compound was evaluated for its inhibitory activity against the Calpain-1 enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 300nMAssay Description:Compound was evaluated for its inhibitory activity against Cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Michigan State University

LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataKi:  510nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetCaspase-1(Human)
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 900nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-1 enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCaspase-3(Human)
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against human recombinant Caspase-3 enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for its inhibitory activity against the ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Maxim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140548(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for its inhibitory activity against the Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed