BDBM50148911 (3beta)-3-hydroxyurs-12-en-28-oic acid::3beta-hydroxyurs-12-en-28-oic acid::CHEMBL169::Ursolic acid::malol::prunol::urson
SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
InChI Key InChIKey=WCGUUGGRBIKTOS-GPOJBZKASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 112 hits for monomerid = 50148911
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-li...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataKi: 3.40E+3nMAssay Description:Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataKi: 6.40E+3nMAssay Description:Mixed-competitive inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMpH: 6.0 T: 2°CAssay Description:In each 96-well plates (total 200 μL of volume), there were 2 mM p-NPP and PTP1B (0.05-0.1 μg) in a buffer containing 50 mM citrate (pH 6.0...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 9.43E+3nMpH: 6.0Assay Description:PTP1B activity was measured by adding 2mM p-NPP and PTP1B in a 50 mM citrate buffer (pH 6.0, 0.1 M NaCl, 1 mMEDTA, and 1 mM dithiothreitol), with or ...More data for this Ligand-Target Pair
Affinity DataIC50: 416nMAssay Description:The elastase inhibitor activity was examined using N-succinyl-Ala-Ala-Ala-pnitroanilide (STANA) as the substrate and by the measuring of the release ...More data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Ku Leuven
Curated by ChEMBL
Ku Leuven
Curated by ChEMBL
Affinity DataIC50: 1.58E+4nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Ku Leuven
Curated by ChEMBL
Ku Leuven
Curated by ChEMBL
Affinity DataIC50: 1.15E+4nMAssay Description:pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Antagonist activity at Gal4-fused RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.06E+3nMAssay Description:Antagonist activity at full-length RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.41E+3nMAssay Description:Antagonist activity at human His6-tagged RORgamma ligand binding domain (262 to 507 aa) assessed as inhibition of SRC1-4 co-activator peptide recruit...More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of rat DNA polymerase beta in presence of BSAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of rat DNA polymerase beta in absence of BSAMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+4nMAssay Description:Inhibition of COX2 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEnv polyprotein(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells aft...More data for this Ligand-Target Pair
TargetDNA polymerase beta(Homo sapiens (Human))
Virginia Polytechnic Institute And State University
Curated by ChEMBL
Virginia Polytechnic Institute And State University
Curated by ChEMBL
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of DNA polymerase beta (unknown origin) lyase activityMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant PTP1B using pNPP substrate at 37 degC measured after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant PTP1B using p-nitrophenylphosphate as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human recombinant PTP1B using p-NPP as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by micr...More data for this Ligand-Target Pair
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)
Curated by ChEMBL
Universidade Federal Do Rio Grande Do Sul (Ufrgs)
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.58E+4nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human recombinant LARMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase alpha(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human recombinant PTPalphaMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase epsilon(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human recombinant PTPepsilonMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of PTP1B (unknown origin) by pNPP assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.33E+3nMAssay Description:Inhibition of TCPTP (unknown origin) by pNPP assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:In vitro inhibitory concentration against phospholipase A2 of Echis carinatus venomMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:In vitro inhibitory concentration against phospholipase A2 of Naja melanoleuca venomMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibitory concentration against phospholipase A2 of Trimeresurus flavoviridis venomMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of PTP1B mediated pNPP hydrolysisMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose-1-phosphate after 25 minsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
University Of Innsbruck
Curated by ChEMBL
University Of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation coun...More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader bas...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of PTP1B using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of TCPTPMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Korea University
Curated by ChEMBL
Korea University
Curated by ChEMBL
Affinity DataEC50: 4.13E+4nMAssay Description:Agonist activity at human recombinant PPARalpha expressed in HepG2 cells cotransfected with pGL3-PPRE3-TK-luc reporter assessed as beta-galactosidase...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as p...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair
Affinity DataIC50: 5.93E+4nMAssay Description:Inhibition of chicken liver FASN ketoreductase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of chicken liver FASNMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as p-nitrophenol release from pNPP substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Chungnam National University
Curated by ChEMBL
Chungnam National University
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of rat intestinal sucrase using p-nitrophenyl-alpha-d-glucopyranoside as substrate incubated for 10 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of TCPTP (unknown origin) assessed as decrease in p-nitrophenol production from pNPP substrate after 30 mins by HTS7000 bioassay reader an...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as decrease in p-nitrophenol production from pNPP substrate after 30 mins by HTS7000 bioassay reader an...More data for this Ligand-Target Pair