BDBM50157818 (2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-dihydroxy-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione::CHEMBL427502

SMILES Cc1cc(ccc1Br)-n1c(O)c2C3C=CC([C@H](O)[C@@H]3O)c2c1O

InChI Key InChIKey=VSFGIDVAKBHPOE-PDPWUNHUSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50157818   

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157818((2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-...)
Affinity DataKi:  33nMAssay Description:Binding affinity for mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157818((2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-...)
Affinity DataKi:  432nMAssay Description:Binding affinity for androgen receptor in human MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157818((2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157818((2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-...)
Affinity DataIC50:  5.24E+3nMAssay Description:Inhibition of androgen receptor in human MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed