BDBM50157879 CHEMBL1614712

SMILES [H][C@]1(CN2CCC2)C[C@]([H])(C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12

InChI Key InChIKey=AECDBHGVIIRMOI-UHFFFAOYSA-N

Data  70 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 97 hits for monomerid = 50157879   

TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 20nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human GST-tagged IGF-1R (950 to 133 residues) expressed in baculovirus after 5 mins in presence of [gamma33P]-ATP by top count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 65nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 86nMAssay Description:Inhibition of human recombinant IGF-1R N-terminal His-tagged (950 to 1337 residues) expressed in baculovirus infected Sf21 measured after 20 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 86nMAssay Description:Inhibition of human IGF-IR in mouse NWT-21 cells assessed as inhibition of autophosphorylation of IGF-IR at pH 7.2 incubated for 90 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 86nMAssay Description:Inhibition of GST-tagged recombinant human IGF1R ( 950 to 1337 residues) autophosphorylation expressed in mouse NWT-21 cells preincubated for 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 105nMAssay Description:Inhibition of IGF-IR in human MCF7 cells assessed as inhibition of anchorage-independent growth incubated for 30 mins and measured after 3 weeks by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 130nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]-dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 140nMAssay Description:Inhibition of GST tagged human Ins-R expressed in baculovirus at pH 7.6 measured after 20 mins in presence of gamma-[33P]-ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 150nMAssay Description:Inhibition of GST tagged human IGF-IR expressed in baculovirus at pH 7.6 measured after 20 mins in presence of gamma-[33P]-ATP by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 162nMAssay Description:Inhibition of IGF-IR in human MCF7 cells expressing IGF-I assessed as cell survival in the absence of serum incubated for 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 244nMAssay Description:Inhibition of full length insulin receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 420nMAssay Description:Inhibition of GST tagged human Flt-3 expressed in baculovirus at pH 7.6 measured after 15 mins in presence of gamma-[33P]-ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 530nMAssay Description:Inhibition of GST tagged Tek (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP by scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 600nMAssay Description:Inhibition of GST tagged Flt-1 (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 800nMAssay Description:Inhibition of PDGFRalpha-V561D mutant (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 892nMAssay Description:Inhibition of full length insulin receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Ins receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of insulin receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of GST tagged human HER-4 expressed in baculovirus at pH 7.5 measured after 15 mins in presence of gamma-[33P]-ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human IGF-IR expressed in mouse NWT-21 cells assessed as inhibition of proliferative capacity incubated for 72 hrs in presence of serum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ERBB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GST tagged PDGFR-beta (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GST tagged KDR (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP by scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of Ins-R in A14 [Human melanoma] cells assessed as inhibition of autophosphorylation of Ins-R incubated for 90 mins followed by insulin st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetInsulin receptor(Human)TBA
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of GST-tagged recombinant human IR ( 919 to 1343 residues) autophosphorylation expressed in mouse NIH-3T3-A14 cells preincubated for 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of GST tagged chicken c-Src expressed in baculovirus at pH 7.5 measured after 10 mins in presence of gamma-[33P]-ATP by scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of GST tagged human Flt-4 expressed in baculovirus at pH 7.6 measured after 15 mins in presence of gamma-[33P]-ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of FGFR2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ACVR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of GST tagged c-Kit (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of GST tagged c-Met (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of SRC (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of GST tagged FGFR-1 (unknown origin) expressed in baculovirus at pH 7.6 measured after 10 to 30 mins in presence of gamma-[33P]-ATP by sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of GST tagged human HER-2 expressed in baculovirus at pH 7.5 measured after 15 mins in presence of gamma-[33P]-ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of FGFR4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of c-Kit (unknown origin) in human GIST882 cells assessed as inhibition of autophosphorylation of c-Kit incubated for 90 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of EGFR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
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