BDBM50158348 (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate::(2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate)::CHEMBL225155::US10676467, Compound S1P::US11584726, Example S1P::sphingosine 1-phosphate::sphingosine-1-phosphate

SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O

InChI Key InChIKey=DUYSYHSSBDVJSM-KRWOKUGFSA-N

Data  30 IC50  48 EC50

PDB links: 15 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 78 hits for monomerid = 50158348   

TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  8.30nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  8.70nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  44nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  4.5nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand. (Experime...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 1 expressed on CHO cell membranesMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranesMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.0620nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.550nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.260nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  34nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.350nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  79nMAssay Description:Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.470nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.660nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.100nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.700nMAssay Description:Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  164nMAssay Description:Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  121nMAssay Description:Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.0270nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.449nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  270nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  1.10nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  9.20nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  2.90nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.900nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experimen...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  8.70nMAssay Description:Effective concentration against sphingosine 1-phosphate receptor 3 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  8.30nMAssay Description:Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  9.20nMAssay Description:Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  4.5nMAssay Description:Effective concentration against sphingosine-1-phosphate receptor 1 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  270nMAssay Description:Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  2.20nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  1.70nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  37nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  20nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Human)
University of Virginia

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  1.20nMAssay Description:In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioli...More data for this Ligand-Target Pair
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