BDBM50158460 (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone::2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran::3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone::Benzbromarone::CHEMBL388590::US9725430, Compound 1::US9856239, benzbromarone::US9962362, Compound 1::Uroleap (TN)::cid_2333
SMILES CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1
InChI Key InChIKey=WHQCHUCQKNIQEC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 61 hits for monomerid = 50158460
Affinity DataKi: 19nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataKi: 3.70E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Srmlsc
Curated by PubChem BioAssay
Srmlsc
Curated by PubChem BioAssay
Affinity DataIC50: 6.28E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
Affinity DataEC50: 1.72E+4nMAssay Description:Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...More data for this Ligand-Target Pair
Affinity DataIC50: 8.19E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
TargetPhotoreceptor-specific nuclear receptor(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: >3.98E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
TargetIsoform 2 of Nuclear receptor corepressor 2 (TRAC-1)(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 4.81E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
TargetPerilipin-1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.50E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
TargetPerilipin-5(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.88E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:URAT1 (Uric Acid Transporter 1) is expressed on the apical membrane in renal tubules. It mediates the re-uptake of uric acid from the urine into the ...More data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Kakatiya University
Curated by ChEMBL
Kakatiya University
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human MRP1 expressed in Spodoptera frugiperda Sf9 cells assessed as inhibition of NEM-GS-induced vanadate-sensitive ATPase activity mea...More data for this Ligand-Target Pair
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.26E+3nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.31E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of 20-alpha HSD (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human URAT1 expressed in human MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human URAT1-mediated urate uptake in HEK293 cellsMore data for this Ligand-Target Pair
TargetMonocarboxylate transporter 1(Rattus norvegicus (Rat))
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetMonocarboxylate transporter 2(Rattus norvegicus)
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetEyes absent homolog 3 [223-510](Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center
US Patent
Cincinnati Childrens Hospital Medical Center
US Patent
Affinity DataIC50: 1.10E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
TargetEyes absent homolog 3(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center
US Patent
Cincinnati Childrens Hospital Medical Center
US Patent
Affinity DataIC50: 8.30E+3nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center
US Patent
Cincinnati Childrens Hospital Medical Center
US Patent
Affinity DataIC50: 5.38E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataIC50: 4.16E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center
US Patent
Cincinnati Childrens Hospital Medical Center
US Patent
Affinity DataIC50: 5.38E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
TargetEyes absent homolog 3 [223-510](Mus musculus (Mouse))
Cincinnati Childrens Hospital Medical Center
US Patent
Cincinnati Childrens Hospital Medical Center
US Patent
Affinity DataIC50: 1.10E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
TargetEyes absent homolog 3(Homo sapiens (Human))
Cincinnati Childrens Hospital Medical Center
US Patent
Cincinnati Childrens Hospital Medical Center
US Patent
Affinity DataIC50: 8.30E+3nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Human kidney embryonic cells HEK-293T were grown in a petri dish (diameter=10 cm) containing DMEM and 10% of bovine fetal serum culture solution, and...More data for this Ligand-Target Pair
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Jikei University School Of Medicine
Curated by ChEMBL
Jikei University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM) in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Kakatiya University
Curated by ChEMBL
Kakatiya University
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Homo sapiens (human) MRP1 expressed in Sf9 cell membranes assessed as decrease in N-ethyl-maleimide-glutathione-induced inorganic phosp...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Inhibition of human URAT1 expressed in Xenopus oocytes by [14C]urate uptake assayMore data for this Ligand-Target Pair
TargetThiosulfate sulfurtransferase(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)
France
Curated by ChEMBL
France
Curated by ChEMBL
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa IMPDH using IMP as substrate in the presence of NAD+ incubated for 70 secsMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of URAT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair