BDBM50166940 NP-031112::NP-12::Tideglusib::US20230414581, Compound 7::med.21724, Compound 155

SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1

InChI Key InChIKey=PMJIHLSCWIDGMD-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50166940   

TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 60nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 78nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 80nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 139nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 251nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 300nMAssay Description:Inhibition of SARS CoV-2 main protease using DABCYL-KTSAVLQSGFRKM-E(EDANS)-NH2 as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 300nMAssay Description:Inhibition of SARS CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSortase family protein(Staphylococcus aureus)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 600nMAssay Description:Inhibition of Staphylococcus aureus SrtA delta N24 mutant expressed in Escherichia coli BL21 (DE3) using Abz-LPATG-Dnp substrate incubated for 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using Mca-AVLQSGFR-K(Dnp)K as substrate by fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Artivila Biopharma

US Patent
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.00E+3nMAssay Description:First, 200 μM of the compound was added to a 50 mM Tris-HCl (pH 7.5) solution containing 0.05 μg/ml dN-SARM1. Then half of the mixture was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2024
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GSK3beta expressed in Escherichia coli using GS-1 as substrate incubated for 20 mins by gamma[32P]ATP-based scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2017
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of SARS-CoV-2 M-proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:Recombinant SARS-CoV-2 Mpro with native N and C termini was expressed in Escherichia coli, and subsequently purified (Extended Data Fig. 1a, b). The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro expressed in Escherichia coli BL21 (DE3) using Mca-AVLQ SGFR-K(Dnp)K as substrate by EnVision multimode plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetSortase family protein(Staphylococcus aureus)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Staphylococcus aureus SrtA delta N24 mutant expressed in Escherichia coli BL21 (DE3) assessed as reduction in IsdA (64 to 323 residues)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166940(NP-031112 | NP-12 | Tideglusib | med.21724, Compou...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant GSK3beta using GSK3 peptide as substrate preincubated for 15 mins followed by ATP addition and measured after 90 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed