BDBM50168748 (2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid hydroxyamide::CHEMBL183995

SMILES C[C@@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1

InChI Key InChIKey=KPWHSOUKRWDBAT-AZUAARDMSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50168748   

LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  417nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  420nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50168748((2R,3R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  420nMAssay Description:Inhibitory concentration against MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed