BDBM50172078 LY-2801653::Merestinib::US11952364, Example Merestinib

SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1

InChI Key InChIKey=QHADVLVFMKEIIP-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50172078   

TargetTyrosine-protein kinase Mer(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 0.800nMAssay Description:Inhibition of MER (unknown origin) by KINOMEScan assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
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TargetMacrophage-stimulating protein receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:Inhibition of RON (unknown origin) by FISH assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
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TargetTyrosine-protein kinase receptor UFO(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
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TargetHepatocyte growth factor receptor(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataKi:  2nMAssay Description:Inhibition of c-MET (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
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TargetTyrosine-protein kinase receptor UFO(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
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TargetTyrosine-protein kinase receptor UFO(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of human full length AXL after 4 hrs followed by stimulation with human recombinant Gas6 for 15 minutes by cell based assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/4/2017
Entry Details Article
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TargetHepatocyte growth factor receptor(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataKi:  2nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant c-MET (956 to 1390 residues) expressed in Baculovirus infected Sf9 cell expression system asses...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
Copy reaction URL

TargetHepatocyte growth factor receptor(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 4.70nMAssay Description:Inhibition of cMET (unknown origin) by FISH assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetHepatocyte growth factor receptor(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 4.70nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
12/18/2024
Entry Details
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TargetHepatocyte growth factor receptor(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 4.70nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
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TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 7nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/18/2023
Entry Details
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TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 7nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/18/2023
Entry Details
Copy BDB DOIPubMed
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TargetTyrosine-protein kinase receptor UFO(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of AXL (unknown origin) by CEREP assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
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TargetTyrosine-protein kinase receptor UFO(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of human full length AXL by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
9/4/2017
Entry Details Article
Copy BDB DOIPubMed
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TargetMacrophage-stimulating protein receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Inhibition of RON (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
Copy BDB DOIPubMed
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TargetHepatocyte growth factor receptor(Human)TBA

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant c-MET (956 to 1390 residues) expressed in Baculovirus infected Sf9 cell expression system by EL...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
Copy reaction URL

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 109nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetCytochrome P450 2C9(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 4.20E+3nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/27/2024
Entry Details
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TargetCytochrome P450 3A4(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/27/2024
Entry Details
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TargetCytochrome P450 2D6(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/27/2024
Entry Details
Copy BDB DOIUS Patent

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TargetCytochrome P450 1A2(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/27/2024
Entry Details
Copy BDB DOIUS Patent

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TargetCytochrome P450 2C19(Human)
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED

US Patent

LigandBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Human liver microsome solution prepared according to the following table (diluted with potassium phosphate solution) Protein con. of working Final pr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
6/27/2024
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL