BDBM50177909 CHEMBL3814819
SMILES CN1CCN(CCn2cc(cn2)-c2cnc(N)c(n2)-c2nc3ccccc3n2-c2cccc(NC(=O)C=C)c2)CC1
InChI Key InChIKey=LJPDEFDDANVUMG-UHFFFAOYSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50177909
Affinity DataEC50: 15nMAssay Description:Inhibition of EGFR exon19 deletion activating mutant autophosphorylation in human PC9 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 2.31E+3nMAssay Description:Inhibition of wild-type EGFR autophosphorylation in human LoVo cells incubated for 2 hrs followed by EGF-stiumlation for 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Inhibition of EGFR T790M/L858R double mutant autophosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair