BDBM50178192 CHEMBL3814772::US10206931, Example 123

SMILES C[C@@H]1CC(=O)Nc2ccc(cc2N1)O[C@H](C)c3ccccc3

InChI Key InChIKey=ORPRVEZBBPKRRY-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50178192   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50178192(CHEMBL3814772 | US10206931, Example 123)
Affinity DataIC50: 652nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50178192(CHEMBL3814772 | US10206931, Example 123)
Affinity DataIC50: 4.10E+3nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178192(CHEMBL3814772 | US10206931, Example 123)
Affinity DataIC50: 8.50E+3nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM50178192(CHEMBL3814772 | US10206931, Example 123)
Affinity DataIC50: 1.29E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent