BDBM50179008 CHEMBL204813::sanggenon C

SMILES [#6]\[#6](-[#6])=[#6]/[#6][C@]12[#8]-c3cc(-[#8])c(-[#6@H]-4-[#6]=[#6](-[#6])-[#6]-[#6@@H](-[#6@H]-4-[#6](=O)-c4ccc(-[#8])cc4-[#8])-c4ccc(-[#8])cc4-[#8])c(-[#8])c3-[#6](=O)[C@@]1([#8])[#8]-c1cc(-[#8])ccc21

InChI Key InChIKey=XETHJOZXBVWLLM-HUKCQOFTSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50179008   

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology (Kribb)

Curated by ChEMBL
LigandPNGBDBM50179008(CHEMBL204813 | sanggenon C)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology (Kribb)

Curated by ChEMBL
LigandPNGBDBM50179008(CHEMBL204813 | sanggenon C)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of VHR DS-PTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50179008(CHEMBL204813 | sanggenon C)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50179008(CHEMBL204813 | sanggenon C)
Affinity DataIC50:  8.26E+3nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50179008(CHEMBL204813 | sanggenon C)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed